First, it was mushrooms in your coffee. Then protein in your soda. The latest wellness staple sneaking into your pantry is creatine. In the days of yore, creatine supplements were a muscle-bro staple, relegated to the lockers of bodybuilders and collegiate linebackers. Lately, it has muscled its way into Pilates studios, gym girlies’ TikToks, and longevity wellness retreats.

“Creatine has been gaining popularity among women across different age groups,” says Gretchen Zimmermann, a registered dietitian. “We do see women who are lifting heavier, and there used to be this thing that was circulating a decade or two ago, where women thought that if they lifted heavy, they would get bulked up. Now we know that’s not true, and naturally there’s some interest in creatine for that reason.”

But what is creatine? Here’s everything you need to know.

Updated February 2026: I’ve added Onnit Creatine to our Honorable Mentions. We also updated links and prices.

Creatine, Explained

Creatine is a compound your body produces in the liver, kidneys, and pancreas, according to Federica Amati, a medical scientist and registered public health nutritionist. Most of it ends up in your skeletal muscles, where it’s stored as phosphocreatine and used to regenerate adenosine triphosphate (ATP), the molecule that powers muscle contractions, nerve signals, and protein synthesis for tissue repair. The rest—less than 5 percent—is found in brain tissue and the testes.

You make about a gram of creatine a day from three amino acids: arginine, glycine, and methionine. You also get more from animal-based foods like red meat, fish, and poultry. For most healthy people, that’s enough. So creatine supplements aren’t essential for general health, but they can boost performance and recovery under the right conditions.

How Creatine Works in the Body

ATP is your cells’ main energy source. High-intensity exercise drains it fast, breaking ATP down into adenosine diphosphate (ADP). Creatine phosphate donates a phosphate group to ADP, recycling it back into ATP almost immediately. The more phosphocreatine stored in your muscles, the faster you can regenerate ATP and the more power you can produce in short bursts.

The Best Form of Creatine

Nowadays, step into any GNC, and you’ll find several forms of creatine: creatine hydrochloride, magnesium creatine chelate, creatine citrate, creatine nitrate, creatine ethyl ester, and buffered creatine. But creatine monohydrate is the most studied, the most effective, and usually the cheapest, according to the International Society of Sports Nutrition. No other form has shown any additional benefits, confirms Amati.

Creatine monohydrate is typically sold as a flavorless, white powder that you can mix into water or a shake. According to Amati, the standard dose is 3 to 5 grams per day. Some athletes may “load” with higher doses, but studies show that this offers no long-term benefits and can put unnecessary stress on the kidneys.

Muscle Growth and Exercise Performance

Creatine is most useful for activities that demand short, intense effort: sprinting, weightlifting, and high-intensity interval training, to name a few. It’s far less relevant for endurance sports like marathons. Some evidence suggests creatine also increases muscle glycogen storage, which could help with recovery and energy replenishment between sessions.

Creatine doesn’t directly build muscle, but paired with resistance training and adequate nutrition, it can help preserve muscle strength and lean body mass. It’s particularly important if you’re recovering from an injury, or as you age, when sarcopenia (age-related muscle loss) becomes a risk, as it activates specialized stem cells known as satellite cells. Zimmermann points out that women, especially in perimenopause and menopause, may see health benefits. “As women get older—starting in our forties—we lose body mass 1 to 2 percent a year, and that can affect bone health later on in life,” says Zimmermann. “Creatine [supplements] support keeping and building lean muscle mass.”

Zimmermann adds, “Women tend to have lower muscle mass than men, just naturally, so I think women may actually respond better to supplementation, because they’re at baseline.”

Creatine and Brain Health

While the effects of creatine supplementation on athletic performance are well-documented, its effects on mental performance are still emerging. Early findings are promising. Studies suggest it may reduce mental fatigue, especially during high-stress situations, such as sleep deprivation or exhaustive exercise. It may also improve certain aspects of memory, particularly in groups with lower baseline creatine levels, such as vegetarians and older adults.

Some preliminary research even suggests it could help with symptoms of depression by supporting brain energy and boosting the production of feel-good neurotransmitters like dopamine and serotonin. That’s particularly relevant for women experiencing perimenopause and menopause, says Zimmermann. “Estrogen shifts affect brain health, our mood, brain fog, and our ability to think clearly.”

Is Creatine Safe?

For most healthy adults, creatine is a safe and well-tolerated supplement for months or even years of use. Short-term and long-term clinical trials have found no significant health risks. The main side effects are minor: weight gain from temporary water retention in the first week of supplementation, bloating, and mild gastric discomfort, usually from oversized doses.

However, there are a few considerations to keep in mind:

• People with kidney disease should avoid creatine unless cleared by a health care professional.
• The American Academy of Pediatrics recommends against creatine use in people under 18 due to limited research on its long-term effects in children and young adults.
• The Food and Drug Adminstration doesn’t regulate dietary supplements for label accuracy or purity. Choose a reputable brand with third-party testing to ensure you’re getting a product that is what it says it is. Also, skip the creatine gummies.

Our Favorite Creatine Supplements

Best Overall

Thorne offers a colorless, odorless, and, most importantly, flavorless powder that dissolves into protein shakes, smoothies, or just water. While it does offer flavors like strawberry and pineapple-orange, I always choose an unflavored version when available, so that I’m not consuming unnecessary additives. Each small scoop delivers a solid 5 grams of creatine. Thorne also sells stick-pack single servings for on-the-go convenience.

Thorne is one of the wellness brands I trust the most because its dietary supplements all undergo four rounds of testing. First, they screen raw materials for contaminants. During the manufacturing process, they check the supplement bottles and labels for defects. They test the finished products for purity and potency, ensuring no microbiological contamination has occurred. Lastly, they perform stability testing to confirm its label claims through the expiration date.

Best Small-Batch Tub

Onnit sells its creatine in three sizes. The 90-serving tub is the best value if you’re consistent, but the 30-serving size is ideal for travel. It’s compact enough to toss into your gym bag if you’re commuting and prefer to take your supplements on-site. The $15 price tag makes it especially appealing if you’re experimenting with creatine for the first time. You’ll get 5 grams per serving with two scoops, but you can start with a single scoop for a couple of days to test the waters. The powder is colorless and flavorless, and it dissolves well in water, which is what you want from a creatine supplement.

Best Value

This creatine powder is tasteless and odorless, and it comes with a nice 5-gram scoop that allows you to easily measure how much you’ve put in your drink. It’s easy to store, gives you about 100 5-gram servings, and comes in a nondescript bottle that won’t make you feel like you’re some fitness influencer. I have enjoyed it in coffee, tea, and just plain water, though I’d recommend sticking to only 5 grams per drink; it can get a bit chalky if you try to do more in 8 ounces of water. —Parker Hall

Best Flavors

Sticking to a daily regimen of any kind is difficult for me, but this creatine is truly so delicious that I look forward to drinking it every day. I tried the pink lemonade flavor, which is tart and sweet. There are other fruity flavors available, like Peach and Strawberry Açai, as well as an unflavored version. Each serving contains 5 grams of creatine, plus a gram each of collagen and BCAAs. I don’t particularly care about the collagen, since the science around it is minimal, but BCAAs can help build muscle as well as ease muscle soreness.

While Peach Perfect is marketed towards building your booty, creatine can help build muscle everywhere. I definitely noticed a difference while lifting weights during the week when I ran out of this powder (before I set up a subscription on Amazon). The supplement dissolves quickly and has a pleasant, non-gritty texture. I’ve even mixed it in my daily dose of greens. The supplement undergoes third-party testing via Eurofins to check for pesticides, heavy metals, and other contaminants. —Louryn Strampe

Power up with unlimited access to WIRED. Get best-in-class reporting and exclusive subscriber content that’s too important to ignore. Subscribe Today.