The Download: the future of AlphaFold, and chatbot privacy concerns
Plus: Donald Trump is ordering US scientific agencies to deploy AI
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.
What’s next for AlphaFold: A conversation with a Google DeepMind Nobel laureate
In 2017, fresh off a PhD on theoretical chemistry, John Jumper heard rumors that Google DeepMind had moved on from game-playing AI to a secret project to predict the structures of proteins. He applied for a job.
Just three years later, Jumper and CEO Demis Hassabis had led the development of an AI system called AlphaFold 2 that was able to predict the structures of proteins to within the width of an atom, matching lab-level accuracy, and doing it many times faster—returning results in hours instead of months.
Last year, Jumper and Hassabis shared a Nobel Prize in chemistry. Now that the hype has died down, what impact has AlphaFold really had? How are scientists using it? And what’s next? I talked to Jumper (as well as a few other scientists) to find out. Read the full story.
—Will Douglas Heaven
The State of AI: Chatbot companions and the future of our privacy
—Eileen Guo & Melissa Heikkilä
Even if you don’t have an AI friend yourself, you probably know someone who does. A recent study found that one of the top uses of generative AI is companionship: On platforms like Character.AI, Replika, or Meta AI, people can create personalized chatbots to pose as the ideal friend, romantic partner, parent, therapist, or any other persona they can dream up.
Some state governments are taking notice and starting to regulate companion AI. But tellingly, one area the laws fail to address is user privacy. Read the full story.
This is the fourth edition of The State of AI, our subscriber-only collaboration between the Financial Times and MIT Technology Review. Sign up here to receive future editions every Monday.
While subscribers to The Algorithm, our weekly AI newsletter, get access to an extended excerpt, subscribers to the MIT Technology Review are able to read the whole thing on our site.
The must-reads
I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.
1 Donald Trump has signed an executive order to boost AI innovation
The “Genesis Mission” will try to speed up the rate of scientific breakthroughs. (Politico)
+ The order directs government science agencies to aggressively embrace AI. (Axios)
+ It’s also being touted as a way to lower energy prices. (CNN)
2 Anthropic’s new AI model is designed to be better at coding
We’ll discover just how much better once Claude Opus 4.5 has been properly put through its paces. (Bloomberg $)
+ It reportedly outscored human candidates in an internal engineering test. (VentureBeat)
+ What is vibe coding, exactly? (MIT Technology Review)
3 The AI boom is keeping India hooked on coal
Leaving little chance of cleaning up Mumbai’s famously deadly pollution. (The Guardian)
+ It’s lethal smog season in New Delhi right now. (CNN)
+ The data center boom in the desert. (MIT Technology Review)
4 Teenagers are losing access to their AI companions
Character.AI is limiting the amount of time underage users can spend interacting with its chatbots. (WSJ $)
+ The majority of the company’s users are young and female. (CNBC)
+ One of OpenAI’s key safety leaders is leaving the company. (Wired $)
+ The looming crackdown on AI companionship. (MIT Technology Review)
5 Weight-loss drugs may be riskier during pregnancy
Recipients are more likely to deliver babies prematurely. (WP $)
+ The pill version of Ozempic failed to halt Alzheimer’s progression in a trial. (The Guardian)
+ We’re learning more about what weight-loss drugs do to the body. (MIT Technology Review)
6 OpenAI is launching a new “shopping research” tool
All the better to track your consumer spending with. (CNBC)
+ It’s designed for price comparisons and compiling buyer’s guides. (The Information $)
+ The company is clearly aiming for a share of Amazon’s e-commerce pie. (Semafor)
7 LA residents displaced by wildfires are moving into prefab housing 🏠
Their new homes are cheap to build and simple to install. (Fast Company $)
+ How AI can help spot wildfires. (MIT Technology Review)
8 Why former Uber drivers are undertaking the world’s toughest driving test
They’re taking the Knowledge—London’s gruelling street test that bypasses GPS. (NYT $)
9 How to spot a fake battery
Great, one more thing to worry about. (IEEE Spectrum)
10 Where is the Trump Mobile?
Almost six months after it was announced, there’s no sign of it. (CNBC)
Quote of the day
“AI is a tsunami that is gonna wipe out everyone. So I’m handing out surfboards.”
—Filmmaker PJ Accetturo, tells Ars Technica why he’s writing a newsletter advising fellow creatives how to pivot to AI tools.
One more thing
The second wave of AI coding is here
Ask people building generative AI what generative AI is good for right now—what they’re really fired up about—and many will tell you: coding.
Everyone from established AI giants to buzzy startups is promising to take coding assistants to the next level. This next generation can prototype, test, and debug code for you. The upshot is that developers could essentially turn into managers, who may spend more time reviewing and correcting code written by a model than writing it.
But there’s more. Many of the people building generative coding assistants think that they could be a fast track to artificial general intelligence, the hypothetical superhuman technology that a number of top firms claim to have in their sights. Read the full story.
—Will Douglas Heaven
We can still have nice things
A place for comfort, fun and distraction to brighten up your day. (Got any ideas? Drop me a line or skeet ’em at me.)
+ If you’re planning a visit to Istanbul here’s hoping you like cats—the city can’t get enough of them.
+ Rest in power reggae icon Jimmy Cliff.
+ Did you know the ancient Egyptians had a pretty accurate way of testing for pregnancy?
+ As our readers in the US start prepping for Thanksgiving, spare a thought for Astoria the lovelorn turkey 🦃
